Revised and updated second edition of the bestselling hands-on guide to building enterprise-ready web apps using an evergreen Angular platformKey FeaturesUpdated examples, projects, and a new ...overview of tools - including NgRX and Ivy, automated testing, and Firebase authenticationNew chapter summarizing history of web frameworks and Angular version updatesAll-new RESTful API implementation leveraging the MEAN stack with MongoDB, Express.js, Angular and Node.jsBook DescriptionThis second edition of Angular for Enterprise-Ready Web Applications is updated with in-depth coverage of the evergreen Angular platform.You'll start by mastering Angular programming fundamentals. Using the Kanban method and GitHub tools, you'll build great-looking apps with Angular Material and also leverage reactive programming patterns with RxJS, discover the flux pattern with NgRx, become familiar with automated testing, utilize continuous integration using CircleCI, and deploy your app to the cloud using Vercel Now and GCloud.You will then learn how to design and develop line-of-business apps using router-first architecture with observable data anchors, demonstrated through oft-used recipes like master/detail views, and data tables with pagination and forms. Next, you'll discover robust authentication and authorization design demonstrated via integration with Firebase, API documentation using Swagger, and API implementation using the MEAN stack.Finally, you will learn about DevOps using Docker, build a highly available cloud infrastructure on AWS, capture user behavior with Google Analytics, and perform load testing. By the end of the book, you'll be familiar with the entire gamut of modern web development and full-stack architecture, learning patterns and practices to be successful as an individual developer on the web or as a team in the enterprise.What you will learnAdopt a minimalist, value-first approach to delivering web appsMaster Angular development fundamentals, RxJS, CLI tools, GitHub, and DockerDiscover the flux pattern and NgRxImplement a RESTful APIs using Node.js, Express.js, and MongoDBCreate secure and efficient web apps for any cloud provider or your own serversDeploy your app on highly available cloud infrastructure using DevOps, CircleCI, and AWSWho this book is forThis book is for developers who want to confidently deliver high-quality and production-grade Angular apps from design to deployment. Developers that have prior experience in writing a RESTful APIs will also benefit, as well as developers who will gain greater awareness of how they fit into the larger picture of delivering a web application. Prior experience with RESTful APIs is desired.
Most contemporary web applications are primarily coded in interpreted languages (JavaScript, PHP, Python...) and are initiated by the web server. This requires solving the persistence issue: ...HTTP/HTTPS is a stateless protocol but user identity and computational state across consecutive requests must be preserved, typically using cookies and/or backend database servers.
This work develops embedded web applications: single compiled executable programs that encapsulate a web server. These applications are coded in a compiled language (in our case, C++). They initiate a separate thread for each session to establish optionally encrypted communication with the client and the HTML5 code for each page is dynamically generated at runtime.
This approach offers several advantages: it enhances security on both the server and client sides. On the server side there is only one file on disk (the executable) that can be altered. On the client side cookies are not needed and client-side code execution can be eliminated. Also, the use of compiled code enhances speed and faster application performance compared to interpreted languages.
This methodology is realized through a framework named EmintWeb (Embedded Interactive Web Development) which comprises a C++ code generator to create the HTML5 pages at runtime and link them with the business logic code of the application. Subsequently, it generates the executable that serves the application. An example of the same application developed using EmintWeb and PHP is provided to evaluate the speed and robustness of both implementations. This approach is not a replacement for current web frameworks but a software system to build web applications using C++ for systems that require the specific characteristics mentioned before.
Learn end-to-end automation testing techniques for web and mobile browsers using Selenium WebDriver, AppiumDriver, Java, and TestNGKey FeaturesExplore the Selenium grid architecture and build your ...own grid for browser and mobile devicesUse ExtentReports for processing results and SauceLabs for cloud-based test servicesUnlock the full potential of Selenium to test your web applications.Book DescriptionSelenium WebDriver 3.x is an open source API for testing both browser and mobile applications. With the help of this book, you can build a solid foundation and can easily perform end-to-end testing on web and mobile browsers.You'll begin by being introduced to the Selenium Page Object Model for software development. You'll architect your own framework with a scalable driver class, Java utility classes, and support for third-party tools and plugins. You'll design and build a Selenium grid from scratch to enable the framework to scale and support different browsers, mobile devices, and platforms.You'll strategize and handle a rich web UI using the advanced WebDriver API and learn techniques to handle real-time challenges in WebDriver. You'll perform different types of testing, such as cross-browser testing, load testing, and mobile testing. Finally, you will also be introduced to data-driven testing, using TestNG to create your own automation framework.By the end of this Learning Path, you'll be able to design your own automation testing framework and perform data-driven testing with Selenium WebDriver.This Learning Path includes content from the following Packt products:Selenium WebDriver 3 Practical Guide - Second Edition by Unmesh GundechaSelenium Framework Design in Data-Driven Testing by Carl CocchiaroWhat you will learnUse different mobile and desktop browser platforms with Selenium 3Use the Actions API for performing various keyboard and mouse actionsDesign the Selenium Driver Class for local, remote, and third-party grid supportBuild page object classes with the Selenium Page Object ModelDevelop data-driven test classes using the TestNG frameworkEncapsulate data using the JSON protocolBuild a Selenium Grid for RemoteWebDriver testingBuild and use utility classes in synchronization, file I/O, reporting and test listener classesWho this book is forThis Learning Path is ideal for software quality assurance/testing professionals, software project managers, or software developers interested in using Selenium for testing their applications. Professionals responsible for designing and building enterprise-based testing frameworks will also find this Learning Path useful. Prior programming experience in Java are TestNG is necessary.
Santrauka. IT pletros konteksto atvilgiu taikomos teisines priemones nesugeba ispresti problemu, su kuriomis tenka susidurti visuomenei, antra vertus, tam tikrais atvejais stabdoma inovaciju ...pletra. Informaciniu sistemu ir technologiju pletros intensyvumas reikalauja labai lanksciu ir adaptyviu kibernetines saugos utikrinimo metodu taikymo budu. Vienas i iu metodu - IT rizikos vertinimas. iuo metu yra daug metodologijij, kuriomis remiantis butu galima efektyviai vertinti kibernetiniu gresmiu rizika. Istaigai, turinciai daugybe riziku, skirtingu poziciju koreliacija gali buti neteisingai ivertinta. inomos rizikos matavimas yra dana rizikos vertinimo praktikos problema. Siekiant sukurti paprasta IT rizikos vertinimo metoda, straipsnyje nagrinejami esami IT rizikos vertinimo metodai, siulomi IT rizikos vertinimo sprendimai ir pateikiami praktinio pritaikymo rezultatai. Reikminiai odiai: IT rizikos, metodas, kibernetinis saugumas, paeidiamumas, gresmes.
Abstract Background Metal ions play vital roles in regulating various biological systems, making it essential to control the concentration of free metal ions in solutions during experimental ...procedures. Several software applications exist for estimating the concentration of free metals in the presence of chelators, with MaxChelator being the easily accessible choice in this domain. This work aimed at developing a Python version of the software with arbitrary precision calculations, extensive new features, and a user-friendly interface to calculate the free metal ions. Results We introduce the open-source PyChelator web application and the Python-based Google Colaboratory notebook, PyChelator Colab. Key features aim to improve the user experience of metal chelator calculations including input in smaller units, selection among stability constants, input of user-defined constants, and convenient download of all results in Excel format. These features were implemented in Python language by employing Google Colab, facilitating the incorporation of the calculator into other Python-based pipelines and inviting the contributions from the community of Python-using scientists for further enhancements. Arbitrary-precision arithmetic was employed by using the built-in Decimal module to obtain the most accurate results and to avoid rounding errors. No notable differences were observed compared to the results obtained from the PyChelator web application. However, comparison of different sources of stability constants showed substantial differences among them. Conclusions PyChelator is a user-friendly metal and chelator calculator that provides a platform for further development. It is provided as an interactive web application, freely available for use at https://amrutelab.github.io/PyChelator , and as a Python-based Google Colaboratory notebook at https://colab.research.google.com/github/AmruteLab/PyChelator/blob/main/PyChelator_Colab.ipynb .
Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers. However, existing web ...applications for DNA methylation analysis does not adequately address the need of experimental biologists, and many additional functions are often required.
To facilitate DNA methylation analysis, we present the SMART (Shiny Methylation Analysis Resource Tool) App, a user-friendly and easy-to-use web application for comprehensively analyzing the DNA methylation data of TCGA project. The SMART App integrates multi-omics and clinical data with DNA methylation and provides key interactive and customized functions including CpG visualization, pan-cancer methylation profile, differential methylation analysis, correlation analysis and survival analysis for users to analyze the DNA methylation in diverse cancer types in a multi-dimensional manner.
The SMART App serves as a new approach for users, especially wet-bench scientists with no programming background, to analyze the scientific big data and facilitate data mining. The SMART App is available at http://www.bioinfo-zs.com/smartapp.
Abstract
Prognostic models that aim to improve the prediction of clinical events, individualized treatment and decision-making are increasingly being developed and published. However, relatively few ...models are externally validated and validation by independent researchers is rare. External validation is necessary to determine a prediction model’s reproducibility and generalizability to new and different patients. Various methodological considerations are important when assessing or designing an external validation study. In this article, an overview is provided of these considerations, starting with what external validation is, what types of external validation can be distinguished and why such studies are a crucial step towards the clinical implementation of accurate prediction models. Statistical analyses and interpretation of external validation results are reviewed in an intuitive manner and considerations for selecting an appropriate existing prediction model and external validation population are discussed. This study enables clinicians and researchers to gain a deeper understanding of how to interpret model validation results and how to translate these results to their own patient population.
Svelte is a modern framework for building static web apps running in the browser that can be used to create fast, lean apps, and which is fun for developers to use. This thorough and quick start ...guide will explore the components of Svelte and have you up and running with building a complete production-ready, static web app in no time.
The rapid expansion of the CRISPR toolbox through tagging effector domains to either enzymatically inactive Cas9 (dCas9) or Cas9 nickase (nCas9) has led to several promising new gene editing ...strategies. Recent additions include CRISPR cytosine or adenine base editors (CBEs and ABEs) and the CRISPR prime editors (PEs), in which a deaminase or reverse transcriptase are fused to nCas9, respectively. These tools hold great promise to model and correct disease-causing mutations in animal and plant models. But so far, no widely-available tools exist to automate the design of both BE and PE reagents.
We developed PnB Designer, a web-based application for the design of pegRNAs for PEs and guide RNAs for BEs. PnB Designer makes it easy to design targeting guide RNAs for single or multiple targets on a variant or reference genome from organisms spanning multiple kingdoms. With PnB Designer, we designed pegRNAs to model all known disease causing mutations available in ClinVar. Additionally, PnB Designer can be used to design guide RNAs to install or revert a SNV, scanning the genome with one CBE and seven different ABE PAM variants and returning the best BE to use. PnB Designer is publicly accessible at http://fgcz-shiny.uzh.ch/PnBDesigner/ CONCLUSION: With PnB Designer we created a user-friendly design tool for CRISPR PE and BE reagents, which should simplify choosing editing strategy and avoiding design complications.
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