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  • Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation (STEMI) -relationship with oxidative stress [Elektronski vir]
    Vukašinović, Aleksandra ...
    Introduction: We aimed to find association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction (AMI). Furthermore, ... association of telomere-telomerase system with oxidative stress markers was tested. Material and methods: Leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into: stabile angina pectoris (AP) (n=22), AMI with: ST-segment elevation (STEMI) (n=93), non-obstructive coronary arteries (MINOCA) (n=7), blood vessel rupture (n=6) in three time points, and compared to with 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group [AP=0.373 (0.355-0.386), STEMI=0.375 (0.349-0.395), MINOCA=0.391 (0.366-0.401), blood vessel rupture=0.360 (0.352-0.385) vs CG=0.069 (0.061-0.081), p=0.000], while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture compared to the control group [STEMI=1.179 (0.931-1.376), MINOCA=1.026 (0.951-1.070), blood vessel rupture=1.089 (0.842-1.173) vs CG=1.329 (1.096-1.624), p=0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to control group and AP patients [5.83 (4.55-7.54) and 10.28 (9.19-10.72) vs 4.94 (3.29-6.18) and 4.18 (2.58-4.86), p=0.000]. Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to peripheral blood leukocytes in the same patients [1.25 (1.01 - 1.84) vs 1.18 (0.909 - 1.516), p=0.036; and 0.366 (0.367 - 0.379) vs 0.366 (0.367 - 0.379), p=0.000, respectively]. Telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from controls. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.
    Vir: Archives of Medical Science [Elektronski vir]. - ISSN 1896-9151 (Vol. 19, no. 2, 2023, str. 1-28)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 105257475

    Povezava(-e):

    https://www.archivesofmedicalscience.com/pdf-136074-64289?filename=Telomere_telomerase.pdf
    https://www.archivesofmedicalscience.com/Telomere-telomerase-system-status-in-patients-with-acute-myocardial-infarction-with,136074,0,2.html
    DOI

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