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  • Activation of the MAP cascade by HIV nef affects the transcription of the pheromone response target gene FUS1 in Saccharomyces cerevisae = Aktivacija MAP kaskade z nef proteinom virusa HIV vpliva na transkripcijo gena FUS1 pri Saccharomyces cerevisiae
    Plemenitaš, Ana, 1952-
    Nef protein from human and simian immunodeficiency viruses plays an important role in the pathogenesis of AIDS. At the molecular level, besides activating tyrosine kinases, Nef activates a cellular ... PAK-like ser/thr kinase. In the present study we show that HIV Nef associates with and activates scr/thr kinase Stc20, a ycast homologue of PAK, in Saccharomyces cerevisiae. The binding of Nef to Ste20 is increased by the additional association of Nef withthe N-terminal SH3 domain of an adaptor protein Beml. By activating Ste20,Nef inereases the transcription of the pheromone response target gene FUSI. Small GTPase Cdc42 and its exchange factor Cdc24 arc required for the effects of Nef on the pheromone response.
    Vir: Acta biologica slovenica : ABS. - ISSN 1408-3671 (Letn. 43, št. 1-2, 2000, str. 11-16)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 12830681

vir: Acta biologica slovenica : ABS. - ISSN 1408-3671 (Letn. 43, št. 1-2, 2000, str. 11-16)

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