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  • Votli nosilci kot nov pristop za vgrajevanje učinkovin v razvoju formulacij s 3D tiskanjem talin = Hollow filaments as a new approach for drug loading in development of melt-based 3D printed formulations : magistrska naloga : enovit magistrski študij farmacija
    Dacar, Zala
    The need for patient-tailored drug dosage development has been well recognized in current medication development and usage. 3D printing is highlighted as a potential strategy to revolutionize the ... personalized medicine field and improve its flexibility, efficiency, safety, and utility. This study aimed to optimize a new and simplified approach to the Fused Deposition Modeling 3D printing technique using hollow filaments (HFs). Computer-aided design of the HF was successfully developed, allowing faster drug loading and, due to the higher filling capacity, higher mass concentrations of the drug compared to the reference model. HFs, printed from commercially available Polylactic acid and Hydroxypropyl Methylcellulose filaments, respectively, were filled with two different drugs (Naproxen or Indomethacin) and fed into the 3D printer. Printing speed, printing temperature, and the adhesion type on the build plate had to be adjusted to successfully achieve the printability of drug-loaded HFs. Not only was the difference in parameters noticeable for different polymers, but also within each polymer with different drugs, indicating the specific drug-polymer interplay had a significant impact on printing outcomes. The mass and dose homogeneity studies between tablets of the same HF showed, that the combinations of the drug and polymer, showing the best miscibility with lower dose variation, in general, had better reproducibility and printability of tablets. The finding suggested that the drug's and polymer's miscibility is crucial in 3D printing success. Predictions of miscibility between different drug-polymer systems, obtained from 3D printing results, were evaluated using Hansen Solubility Parameters (HSPs) method, The Melting Point Depression (MPD) method, and the novel method utilizing The Enthalpy of Melting and Mixing (Hmm). Due to the physicochemical properties of drug-polymer systems that might have affected the analysis outcome of Hmm and MPD, HSPs were found to be the most helpful tool to predict miscibility and explain results acquired from the conducted experiments for these specific drug-polymer systems.
    Vrsta gradiva - magistrsko delo ; neleposlovje za odrasle
    Založništvo in izdelava - Ljubljana : [Z. Dacar], 2022
    Jezik - angleški
    COBISS.SI-ID - 136470531

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
Fakulteta za farmacijo, Ljubljana Knjižnica
emšf 61 DACAR ZALA Votli 1215
IN: 0017628 		prosto - za čitalnico
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