DIKUL - logo
(UL)
  • Design of OSMI-4 analogs using scaffold hopping [Elektronski vir] : investigating the importance of the uridine mimic in the binding of OGT inhibitors
    Balsollier, Cyril ...
    Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein ubiquitous in both pathology and tissue distribution, we report ... phthalazinone–galactals that show excellent selectivity for the galectin-8 N-terminal domain. A dissection of structure-activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis accompany the discovery of the selective galectin-8N ligands presented here. These selective compounds will facilitate the study of galectin-8 biology and may have pharmaceutical relevance in the wide range of galectin-8 associated pathologies.
    Vir: ChemMedChem. - ISSN 1860-7187 (Vol. 18, iss. 8, 2023, str. 1-7)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 141476867

    Povezava(-e):

    https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300001
    DOI

Vnos na polico