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  • Microbiological diagnosis of Lyme borreliosis
    Ružić-Sabljić, Eva
    Lyme borreliosis is a complex multisystem disorder. Clinical manifestations are variable and differential diagnosis is often difficult. Besides clinical criteria (erythema migrans), the diagnosis of ... Lyme borreliosis can be ascertained by demonstration of borrelial infection using either direct (isolation, PCR) or indirect (serology) microbiological tests. Isolation of B.burgdorferi sensu lato from clinical material represents the most reliable method for confirming borrelial infection. PCR has been developed for the detection of B. burgdorferi sensu lato DNA in clinical specimens. In contrast to culture, PCR is a rapid method but it is not standardized. Serologic tests represent the most commonly used method for establishing microbiological diagnosis of borrelial infection. Specific IgM and IgG antibodies can be detected in blood, CSF and synovial fluid. The percentage of seropositivity increases with duration of infection. It is not possible with serologic tests to distinguish between acute, late, active, or treated disease. In patients with Lyme borreliosis a specific T-cell response to B. burgdorferi sensu lato can also be detected.
    Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 10, št. 4, 2001, str. 143-147)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - angleški
    COBISS.SI-ID - 14523353

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