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Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice [Elektronski vir]Untiet, Verena ...Information transfer within neuronal circuits depends on the balance and recurrent activity of excitatory and inhibitory neurotransmission. Chloride (Cl−) is the major central nervous system (CNS) ... anion mediating inhibitory neurotransmission. Astrocytes are key homoeostatic glial cells populating the CNS, although the role of these cells in regulating excitatory-inhibitory balance remains unexplored. Here we show that astrocytes act as a dynamic Cl− reservoir regulating Cl− homoeostasis in the CNS. We found that intracellular chloride concentration ([Cl−]i) in astrocytes is high and stable during sleep. In awake mice astrocytic [Cl−]i is lower and exhibits large fluctuation in response to both sensory input and motor activity. Optogenetic manipulation of astrocytic [Cl−]i directly modulates neuronal activity during locomotion or whisker stimulation. Astrocytes thus serve as a dynamic source of extracellular Cl− available for GABAergic transmission in awake mice, which represents a mechanism for modulation of the inhibitory tone during sustained neuronal activity.Vir: Nature communications [Elektronski vir]. - ISSN 2041-1723 (Vol. 14, iss. [article no.] 1871, 2023, str. 1-14)Vrsta gradiva - e-članekLeto - 2023Jezik - angleškiCOBISS.SI-ID - 178415107
Avtor
Untiet, Verena |
Beinlich, Felix R. M. |
Kusk, Peter |
Kang, Ning |
Ladrón-de-Guevara, Antonio |
Song, Wei |
Kjaerby, Celia |
Andersen, Mie |
Hauglund, Natalie |
Verkhratsky, Alexei
Teme
astrocytes |
chloride |
brain |
neurotransmission |
mice |
astrociti |
klorid |
možgani |
nevrotransmisija |
miši
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Untiet, Verena | ![]() |
Beinlich, Felix R. M. | ![]() |
Kusk, Peter | ![]() |
Kang, Ning | ![]() |
Ladrón-de-Guevara, Antonio | ![]() |
Song, Wei | ![]() |
Kjaerby, Celia | ![]() |
Andersen, Mie | ![]() |
Hauglund, Natalie | ![]() |
Verkhratsky, Alexei | 37641 |
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