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  • Rastni hormon pri funkcionalni androgenizaciji : doktorsko delo = Growth hormone in functional hyperandrogenism
    Legan, Mateja
    Insulin resistance and hyperinsulinism are now well recognized features of obese women witl functional hyperandrogenism (FH) and accepted pathogenetic factor of disorder in obese patients Non-obese ... women with FH have less expressed insulin resistance and higher serum growth hormone (GH) concentrations. Our hypothesis was that GH and peripheral markers of its influence (IGF-I, GHBP, IGFBP-3) correlate importantly with degree of androgenemia (concentrations of serum androgens) as well as with other characteristics (higher bone mineral density) in non-obese women with FH. In prospective clinical study, eighteen androgenized women were enrolled, aged 18to 35 years of normal body weight (within +/- 20 % according to Metropolitane Life Inssurance Tables) with clinical signs of hyperandrogenism (hirsutism andžor acne andžor androgenic alopecia) and increased serum concentration of at least one of determined serum androgens. Ten of them were eumenorrhoeic, 8 oligomenorrhoeic. Other endocrinological diseases with androgen excess were excluded. Ten healthy eumenorrhoeic counterparts (age andweight matched) formed a control group. In the early follicular phase a blood sample was obtained for determinating plasmč concentrations of free testosterone (FT), androstendione (A), dehydroepiandrosterone sulphate (DHEAS)and estradiol (E2). On random day each participant passed growth hormone releasing hormone test (GHRH test) with basal and consecutive determinations of GH during stimulation During GHRH test we also assesed serumconcentrations of insulin (IRI), insulin-like growtl factor-I (IGF-I), glucose (G), IGF-binding protein-1 (IGFBP-1), IGF-binding protein-3 (IGFBP-3) and GH-binding protein (GHBP). Each participant BMD of lumbar spine (L2 - L4) wa meassured by dual X-ray absorptiometry method. (Abstract truncated at 2000 characters).
    Vrsta gradiva - disertacija
    Založništvo in izdelava - Ljubljana : [M. Legan], 2000
    Jezik - slovenski
    COBISS.SI-ID - 2174740

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
Narodna in univerzitetna knjižnica, Ljubljana GS II 522370 glavno skladišče prosto - za čitalnico
MF, Centralna medicinska knjižnica, Ljubljana doktorske disertacije
LEGAN Matejka Rastni
IN: 020000813 		prosto - na dom, čas izposoje: 1 mes.
MF, Centralna medicinska knjižnica, Ljubljana doktorske disertacije
LEGAN Matejka Rastni
IN: 020000814 		prosto - na dom, čas izposoje: 1 mes.
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