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  • Pomanjkanje rastnega hormona pri odraslih : vpliv nadomestnega zdravljenja z rekombinantnim humanim rastnim hormonom na aterogenezo = Growth hormone (GH) deficiency in adults : effects of recombinant human GH replacement on atherogenesis : doktorsko delo
    Pfeifer, Marija
    Human pituitary secretes growth hormone (GH) throughout the lifespan. In adulthood GH is one of the most important regulators of metabolic processes inthe human bodyČ it enhances lipolysis and lipid ... oxidation, protein synthesisand sodium and water retention. It regulates body composition and function. Adults who are deficient in GH exhibit a number of abnormal featuresincluding increased adiposity and decreased lean body mass associated with reduced physical fitness. They have increased prevalence of risk factors for atherosclerosisČdyslipidemia, insulin resistance, impaired glucose tolerance, increased fibrinogen, plasminogen activator inhibitor and hypertension. They exhibit increased mortality from cardiovascular, especiallycerebrovascular disease. As GH replacement therapy reduced or abolished most of the risk factors for atherosclerosis in hypopituitary GH deficient adults, it was hypothesised that GH replacement would reverse early functional and morphological signs of atherogenesis. Insulin-tolerance test (ITT) is the Ćgold standardĆ for assessment of GH reserve. In our study three consecutive ITTs were performed in seven normal adult men and two ITTs in 11 men with hypopituitarism ITTs were performed in seven normal adult men and twoITTs in 11 men with hypopituitarism and suspected GH deficiency. We assessed the reproducibility and variability of GH responses. In normal men the within subject peak GH variability was between 5-60%, and the overall variability in 21 tests was 35%. The lowest peak GH concentration was 27 ugžl.All hypopituitary men had severe GH deficiency (all peak GH concentrations < 1.5 ugžl in both tests). There was a highly significant correlation between individual peak GH values in patients, but not in healthy men. (Abstract truncated at 2000 characters).
    Vrsta gradiva - disertacija ; neleposlovje za odrasle
    Založništvo in izdelava - [Ljubljana] : [M. Pfeifer], 2001
    Jezik - slovenski, angleški
    COBISS.SI-ID - 2329876

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
Narodna in univerzitetna knjižnica, Ljubljana GS II 527574 glavno skladišče prosto - za čitalnico
MF, Centralna medicinska knjižnica, Ljubljana doktorske disertacije
PFEIFER Marija Pomanjkanje
IN: 020010986 		prosto - na dom, čas izposoje: 1 mes.
MF, Centralna medicinska knjižnica, Ljubljana doktorske disertacije
PFEIFER Marija Pomanjkanje
IN: 020010987 		prosto - na dom, čas izposoje: 1 mes.
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