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  • Recurrent fever in children as a diferential diagnostic challenge = Diagnostični pristop k otrkou s ponavljajočimi vročinskimi stanji
    Toplak, Nataša, 1967-, pediatrija
    The approach to a child with a prolonged, recurrent or periodic fever presentsa diagnostic challenge. A careful history, physical examination, laboratory testing and imaging studies are needed in ... order to exclude acute orchronic infection, anatomical defects, immunodeficiency, and autoimmune and malignant diseases. Periodic fever syndromes are defined as three or more episodes of unexplained fever in a 6-month period, occurring at least 7 days apart. Specific genetic mutations have been discovered for these syndromes. Sporadic conditions, such as Periodic fever syndrome with aphthous stomatitis,pharyngitis and cervical adenopathy have also been recognized. Periodic fever syndromes belong to a group of autoinflammatory disorders in which no pathogen, autoantibodies or antigen specific T cells can be found. They are caused by mutations in proteins that modulate the activity of the inflammasome. Because of the defective innate immune response these diseases are listed among the primary immunodeficiencies.
    Vir: Slovenska pediatrija : revija Združenja pediatrov Slovenije in Združenja specialistov šolske in visokošolske medicine Slovenije. - ISSN 1318-4423 (Letn. 15, št. 1, 2008, str. 24-29)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24521433

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