-
Modulation of hepatic transcriptomein the poloxamer P-407 hyperlipidemia mouse modelKuzman, Drago ...The poloxamer P-407 hyperlipidemia mouse is a genetically unaltered, nondiet-induced model of atherosclerosis which is useful in studying effects of lipid lowering drugs. While the model is ... relatively well described on the biochemical level, the knowledge regarding the global gene expression was lacking so far. As expected, the P-407 elevates plasma triglycerides and cholesterol. Using microarray analysis and RT-PCR we show for the first time that poloxamer triggers a concerted modulation of hepatic genes involved in multiple steps of atherogenesis, such as lipid metabolism, initiation of atherogenesis, lesion formation, and atheroma progression. 106 hepatic genes were upregulated and only 40 downregulated, suggesting that upregulation of atherogenic genes precedes the atheroma formation. Modulated expression of circadian genes has also been observed in this type of hyperlipidemia but further studies are needed to elucidate whether this effects the rhythm of animals.Vir: Acta chimica slovenica. - ISSN 1318-0207 (Letn. 56, 2009, str. 262-269)Vrsta gradiva - članek, sestavni delLeto - 2009Jezik - angleškiCOBISS.SI-ID - 25453529
Avtor
Kuzman, Drago |
Fon Tacer, Klementina |
Černe, Manica |
Režen, Tadeja |
Ačimovič, Jure |
Čegovnik Primožič, Urška |
Kocjan, Darko |
Urleb, Uroš |
Rozman, Damjana, 1960-
Teme
Hyperlipidemia |
Genetics |
Atherosclerosis |
Hypertriglyceridemia |
Hypercholesterolemia |
Poloxalene |
Disease Models, Animal |
Gene Expression |
Polymerase Chain Reaction |
Mice, Inbred C57bl |
Hiperlipidemija |
Hipertrigliceridemija |
Hiperholesterolemija |
Poloksalen |
Polimerazna, verižna reakcija |
Bolezen, živalski modeli |
Gensko izražanje |
Miši seva C57BL
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Kuzman, Drago | 18355 |
Fon Tacer, Klementina | 20347 |
Černe, Manica | 05088 |
Režen, Tadeja | 22459 |
Ačimovič, Jure | 28352 |
Čegovnik Primožič, Urška | 18299 |
Kocjan, Darko | 09905 |
Urleb, Uroš | 01878 |
Rozman, Damjana, 1960- | 06013 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.