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Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemiar-reperfusion injury : beyond concentration-dependent antioxidant activityŽiberna, Lovro ...Despite being reported to reduce the risk of cardiovascular diseases, little is known about acute direct effects of bilberry anthocyanins on whole mammalian heart under ischemia-reperfusion (I-R) ... conditions. Bilberry anthocyanins were prepared from the ripe bilberries and analyzed using HPLC-DAD. Their antioxidant activity was evaluated by measuring the intrinsicfree radical-scavenging capacity and by cellular antioxidant assay (CAA) on endothelial cells, where we quantified the intracellular capacity to inhibit the formation of peroxyl radicals. Experiments on the isolated rat hearts under I-R were carried out according to the Langendorff method. Perfusion with low concentrations of bilberry anthocyanins (0.01-1 mg/L) significantly attenuated the extent of I-R injury as evidenced by decreasing the release rate of LDH, increasing the postischemic coronary flow, and by decreasing the incidence and duration of reperfusion arrhythmias. High concentrations (5-50 mg/L) diminished cardioprotection and show cardiotoxic activity despite having their radical scavenging and intracellular antioxidantcapabilities increased in a concentration-dependent manner. This study reveals the biphasic concentration-dependent bioactivity of bilberry anthocyanins under I-R, which results in strong cardioprotective activity in low concentrations and cardiotoxic activity in high concentrations.Vir: Cardiovascular toxicology. - ISSN 1530-7905 (Vol. 10, issue 4, 2010, str. 283-294)Vrsta gradiva - članek, sestavni delLeto - 2010Jezik - angleškiCOBISS.SI-ID - 27568345
Avtor
Žiberna, Lovro |
Lunder, Mojca, dr. med., 1980- |
Može Bornšek, Špela |
Vanzo, Andreja |
Tramer, Federica |
Passamonti, Sabina |
Drevenšek, Gorazd
Teme
Endothelium |
Drug Effects |
Plant Extracts |
Anthocyanins |
Free Radical Scavengers |
Myocardial Reperfusion Injury |
Chromatography, High Pressure Liquid |
Cell Line |
Heart Rate |
Arrhythmia |
Electrocardiography |
Lactate Dehydrogenase |
Rats, Wistar |
Rastlinski izvlečki |
Endotelij |
Prosti radikali, odstranjevalci |
Antocianini |
Miokardna, reperfuzijska poškodba |
Celična linija |
Aritmija |
Podgane, Wistar |
Srčna frekvenca |
Elektrokardiografija |
Kromatografija visokotlačna, tekočinska |
Laktatna dehidrogenaza
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Žiberna, Lovro | 29416 |
Lunder, Mojca, dr. med., 1980- | 28865 |
Može Bornšek, Špela | 29612 |
Vanzo, Andreja | 21399 |
Tramer, Federica | ![]() |
Passamonti, Sabina | ![]() |
Drevenšek, Gorazd | 13310 |
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