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Insulin regulation of proliferation involves activation of AKT and ERK 1/2 signaling pathways in vascular smooth muscle cellsIsenović, Esma R. ...This investigation used primary cultured rat vascular smooth muscle cells (VSMCs) to examine the effects of insulin (INS) on proliferation of VSMCs. In this study, protein kinase B (Akt) and p42/44 ... mitogen-activated protein kinase(ERK 1/2) signaling pathways in mediatingthe mitogenic actions of INS in VSMCs was investigated. Incubation of a rat VSMCs with INS (100 nM) for 10 min. resulted in an increase of Akt phosphorylation by 6-fold (P<0.001) and ERK1/2 phosphorylation by 3-fold (P<0.001). Pretreatment for 15 min with 10 Mof P13 K/Akt inhibitor LY294002 or with 20 M inhibitor of ERK 1/2 PD98059 significantly reduced INS-stimulated Akt and ERK 1/2 phosphorylation by 76% and by 75%, respectively. Incubation of a rat VSMCs with INS resultedin an increase of VSMC proliferation (CONT=100%, INS=187 13%, P<0.001.) The effect of INS on VSMC proliferation was significantly reduced by 68% by pretreatment with LY294002 (P>0.01) and by 71% (P>0.01)by pretreatment with PD98059. These results indicate that INS acts through Akt and ERK 1/2 signaling pathways to up-regulate proliferation of VSMC's.Vir: Experimental and clinical endocrinology & diabetes. - ISSN 0947-7349 (Vol. 117, Issue 5, 2009, Str. 214-219)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 34021125
Avtor
Isenović, Esma R. |
Fretaud, Maxenence |
Koricanac, Goran |
Sudar, Emina |
Velebit Marković, Jelena |
Dobutovic, Branislava |
Marche, Pierre
Teme
vascular smooth muscle cells |
proliferation |
INS |
AKT |
ERK 1/2 |
adipociti |
inzulin |
glukoza |
eksocitoza |
elektorfiziologija |
konfokalna mikroskopija
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vir: Experimental and clinical endocrinology & diabetes. - ISSN 0947-7349 (Vol. 117, Issue 5, 2009, Str. 214-219)
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Isenović, Esma R. | ![]() |
Fretaud, Maxenence | ![]() |
Koricanac, Goran | ![]() |
Sudar, Emina | ![]() |
Velebit Marković, Jelena | 32525 |
Dobutovic, Branislava | ![]() |
Marche, Pierre | ![]() |
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