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The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatinKatanić, Jelena ...The effects of the methanolic extracts of Filipendula hexapetala Gilib. aerialparts (FHA) and roots (FHR) against cisplatin induced kidney and liver injuries in rats were investigated as well as ... determination of genotoxicity and antigenotoxicity of the extracts. Treatment with FHA and FHR significantlydecreased levels of urea, uric acid, serum transaminases, alkaline phosphatase and Ž-glutamyl transferase, and increased the content of total protein. In addition, treatment with the extracts significantly attenuated the cisplatin-induced oxidative stress in kidney and liver tissues by increasing catalase and superoxide dismutase activities and the content of reduced glutathione and decreasing the content of thiobarbituric acid reactivesubstances (TBARS). The histopathological studies confirmed the protective effects of the extracts against cisplatin-induced kidney and liver injuries. The extracts ameliorated cisplatin-induced genotoxicity. These results suggest that F. hexapetala extracts are effective nephro- and hepatoprotective agents, with potential to reduce oxidative stress and ameliorate cisplatin-induced nephro- and hepatotoxicity.Vir: Journal of functional foods. - ISSN 1756-4646 (Vol. 18, part A, 2015, str. 198-212)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2015Jezik - angleškiCOBISS.SI-ID - 3902577
Avtor
Katanić, Jelena |
Mihailović, Vladimir |
Matić, Sanja, biologinja |
Stanković, Vesna, zdravnica |
Stanković, Nevena |
Boroja, Tatjana |
Mladenović, Milan, kemik |
Stanić, Snežana |
Kreft, Samo |
Mihailović, Mirjana, molekularna biologinja
Teme
Filipendula hexapetala |
tekočinska kromatografija visoke ločljivosti |
navadni oslad |
hepatoksičnost |
cisplatin
Vnos na polico
Trajna povezava
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Katanić, Jelena | |
Mihailović, Vladimir | |
Matić, Sanja, biologinja | |
Stanković, Vesna, zdravnica | |
Stanković, Nevena | |
Boroja, Tatjana | |
Mladenović, Milan, kemik | |
Stanić, Snežana | |
Kreft, Samo | 15460 |
Mihailović, Mirjana, molekularna biologinja |
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