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  • Higher glucose level and systemic oxidative stress decrease the mean velocity index of the retinal artery during flickering light stimulation in type 1 diabetes = Visoke razine glukoze i sustavni oksidativni stres kod pacijenata s dijabetesom tipa 1 smanjuju indeks srednje brzine strujanja krvi u retinalnoj arteriji za vrijeme stimulacije treperećim svjetlom
    Debelić, Vladimir ...
    Aim To determine whether higher glucose level and sys- temic oxidative stress decrease mean velocity (MV ) index of the central retinal artery (CRA) during flickering light stimulation in type 1 ... diabetes (T1D). Methods The study was performed in the period from 2008 to 2015 at the University Eye Clinic in Ljubljana. 41 pa- tients with T1D and 37 participants without diabetes were included. MV in the CRA was measured using Doppler ul- trasound diagnostics in basal conditions and during 8 Hz flickering light irritation. The plasma levels of glucose, fruc- tosamine, 8-hydroxy-2'-deoxyguanosine (8-OHdG), triglyc- erides, cholesterol, and low-density lipoprotein (LDL) were measured. Results Patients with T1D had significantly higher levels of blood glucose ( P < 0.001), fructosamine ( P < 0.001), and 8-OHdG ( P < 0.001), but there were no significant differences in triglycerides ( P = 0.108), cholesterol ( P = 0.531), and LDL ( P = 0.645) between the groups. Patients with T1D also had a significantly lower MV index in the CRA (1.11 0.15 vs 1.24 0.23; P = 0.010). In the T1D group, a significant negative correlation was found between the level of glucose (r = 0.58; P < 0.001), fructosamine (r = 0.46; P = 0.003), 8-OHdG (r = 0.48; P = 0.002) and the MV index in the CRA. At the same time, in this group fructosamine and 8-OHdG levels had a separate effect on the MV index (adjusted R 2 = 0.38, P < 0.001). Conclusion Higher glucose levels, the medium-term glu- cose level, and systemic oxidative stress could importantly reduce retinal vasodilatation during flickering light irrita- tion in patients with T1D.
    Vir: Croatian medical journal. - ISSN 0353-9504 (Vol. 57, no. 5, 2016, str. 434-441)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 4284785

    Povezava(-e):

    http://www.cmj.hr/default.aspx?id=12699&issue=yes
    http://www.cmj.hr/2016/57/5/27815934.htm
    DOI

vir: Croatian medical journal. - ISSN 0353-9504 (Vol. 57, no. 5, 2016, str. 434-441)

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