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Personalized laboratory medicine [Elektronski vir] : a patient-centered future approachProdan Žitnik, Irena ...In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment ... at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of %omics% technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient%s status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.Vir: Clinical chemistry and laboratory medicine. - ISSN 1437-4331 (Vol. 56, iss. 12, 2018, str. 1981-1991)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2018Jezik - angleškiCOBISS.SI-ID - 4561009
Avtor
Prodan Žitnik, Irena |
Černe, Darko |
Mancini, Irene |
Simi, Lisa |
Pazzagli, Mario |
Di Resta, Chiara |
Podgornik, Helena |
Repič-Lampret, Barbka |
Trebušak Podkrajšek, Katarina |
Marc, Janja
Teme
Diagnostika |
advanced omics technologies |
diagnostic marker |
genome |
metabolome |
molecular profiling |
proteome |
transcriptome
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Prodan Žitnik, Irena | 22657 |
Černe, Darko | 15099 |
Mancini, Irene | ![]() |
Simi, Lisa | ![]() |
Pazzagli, Mario | ![]() |
Di Resta, Chiara | ![]() |
Podgornik, Helena | 12684 |
Repič-Lampret, Barbka | 14020 |
Trebušak Podkrajšek, Katarina | 20253 |
Marc, Janja | 12189 |
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