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  • Eoziofilni kationski protein pri bolnikih z astmo zdravljenih s ciklosporinom = The eosinophilic cationic protein in patients with asthma treated with the cyclosporine
    Turel, Matjaž ; Šuškovič, Stanislav ; Pohl, Wolfgang
    Background. Asthma is a chronic inflammatory airway disease in which many cells including eosinophils play a role in pathogenesis. Corticosteroids in inhalation are currently the most effective ... anti-inflammatory drugs for the treatment of astbma. The main goal in the systemic steroid dependent asthmatics (SDA) is to reduce steroid side effects by using other effective antiinflammatory drug. Cyclosporine A is an immunosupresive drug with potentially beneficial effect on airways inflammation. The main goal of this study was to investigate if low doses one week treatment with CyA influenced eosinophilic cationic protein (ECP) and airway obstruction. Patients and methods. Twelve SDA (group A) were treated with CyA (2mg/kg/day) for one week. Eight asthmatics who didn't regularly use systemic corticosteoids (group B) were treated with 40 mg methyleprednisolone (MDA) daily. Eight healthy atopics without history of asthma (group C) was the second control group. In groups A and B blood samples were collected every four hours the day before and the last day of the treatment. Corresponding measurements in the group C were performed only one day. In the group A also peak expiratory flow rate (PEF) was measured together with blood concentration of yhe CyA. Results. In the group A ECP concentration and PEF did not change significantly during the treatment with CyA. No corelations between blood concentration of the CyA and serum ECP concentration or PEF were demonstrated. In the group B statistically significant (p<0.05) differences in the serum ECP before and after the treatment with MDA (at4PM, 8PM and 4AM) were found. Conclusions. We conclude that short treatment with the low doses of CyA is not likely to influence serum ECP concentrations and the degree of airway obstruction. Low doses of the CyA are therefore not likely to significantly decreased production and release of the lymphokines, which are responsible for the proliferation and activation of the eosinophils.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Let. 65, Suppl. 2, 1996, str. II-19-II-22)
    Vrsta gradiva - članek, sestavni del
    Leto - 1996
    Jezik - slovenski
    COBISS.SI-ID - 4833241

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