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The potential of nanofibers to increase solubility and dissolution rate of the poorly soluble and chemically unstable drug lovastatinKajdič, Saša ...Polymer nanofibers represent a promising drug delivery system. However, as a large surface area is exposed to external conditions during the electrospinning process, they are usually used to ... incorporate drugs with good oxidative stability. Here, we introduce a new concept for the incorporation of a drug with low oxidative stability and extremely low solubility into poloxamer 188/ poly(ethylene oxide) and Soluplus/ poly(ethylene oxide) nanofibers, to improve its solubility and increase its dissolution rate. The electrospun products showed different morphologies and lower initial lovastatin contents than theoretically expected, which indicated oxidative drug degradation during electrospinning. The addition of antioxidants improved the lovastatin chemical stability in the nanofibers. The highest lovastatin dissolution rate and solubility were obtained for the Soluplus-based nanofibers, where no crystalline lovastatin was detected. The accelerated stability study has revealed the chemical stability of lovastatin in the poloxamer-based nanofibers with the addition of antioxidants, whereas in the Soluplus-based nanofibers lovastatin was not completely preserved. However, appropriate packaging of the formulation and storage under normal conditions is expected to assure its stability. These Soluplus-based nanofibers developed here with antioxidants represent a promising immediate release formulation to provide improved solubility and dissolution rate for poorly soluble and chemically unstable drugs, such as lovastatin.Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 573, 2020, str. 1-10)Vrsta gradiva - članek, sestavni delLeto - 2020Jezik - angleškiCOBISS.SI-ID - 4838513
Avtor
Kajdič, Saša |
Zupančič, Špela, farmacevtka |
Roškar, Robert, 1975- |
Kocbek, Petra, farmacevtka
Teme
Nanomateriali |
Nanotehnologija |
lovastatin |
electrospinning |
immediate drug release |
nanofibers |
stability |
drug dissolution |
polimerna nanovlakna |
topnost učinkovin |
kemična stabilnost
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kajdič, Saša | ![]() |
Zupančič, Špela, farmacevtka | 36439 |
Roškar, Robert, 1975- | 23549 |
Kocbek, Petra, farmacevtka | 24402 |
Vir: Osebne bibliografije
in: SICRIS
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