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  • The effects of equinatoxin II on respiration - possible mechanism on the toxin lethality
    Bunc, Matjaž ...
    In rat an intravenous application (i.v.) of a lethal dose of the equinatoxin II (EqT II) provoked a respiratory arrest. It is not known whether the respiratory arrest is a result of a direct actions ... of the toxin on lung tissue, on neuromuscular junctions or the on the central nervous system. The influences of the toxin on the neuromuscular transmission and on muscular contraction were studied in isolated rat diaphragm. The effect of EqT II on end plate potentials of m. cutaneus pectoris was measured in the frog Rana esculenta. To monitor equinatoxin II effects on the central nervous system of a rat, the toxin was injected directly into the forth brain ventricle. The respiratory arrest was not the result of the toxin action on the neuromuscularjunctions and peripheral nerves. The cessation of respiratory activity was most probably a result of equinatoxin II direct actions on lung tissue and on brain microcirculation.
    Vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 439, št. 3, suppl., 2000, str. R129-R130)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 783738

vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 439, št. 3, suppl., 2000, str. R129-R130)

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