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  • Subchronic liver injuries caused by microcystins
    Frangež, Robert ...
    The subchronic effects of cyanobacterial lyophilizate (CL) containing microcystins on liver were investigated in female New Zeland rabbits. Sterilised CL containing microcystins was injected i.p. ... Liver toxicity was assessed by histological examination of liver samples. Noninvasive magnetic resonance imaging (MRI) of liver was also peformed in order to assess changes in the homogeneity of liver tissue. Subchronical intoxication with microcystins caused morphological changes of liver tissue that were also detected by use of MRI. Histological analysis showed that changes seen on MRI represent liver injury characterised with fatty infiltration and periportal fibrosis. This demonstrates that subchronic exposure to microcystins can lead to liver degeneration, which can easily be detected in vivo by use of MRI.
    Vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 440, Suppl. 5, 2000, str. R 103- R 104)
    Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasle
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 946554

vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 440, Suppl. 5, 2000, str. R 103- R 104)

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