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  • Assessment of kainate toxicity using contrast enhanced magnetic resonance imaging
    Beravs, Katarina ; Frangež, Robert ; Demšar, Franci
    The purpose of this study was to test the capability of contrast enhanced magnetic resonance imaging (MRI) in assessing lesion formation in rat brain after systemic (i.v.) administration of kainate. ... MRI was performed with T1-weighted spin echo sequence before and after the administration of kainate and contrast media. Contrast media used were based on paramagnetic gadolinium (III) ionČ Gd-DTPA (gadoliniumdiethylene-triaminepentaacetic acid) and prototype agents for blood-pool enhancement Gadomer-17 and polylysine-Gd-DTPA.Enhancement of lesion rims and other brain tissue abnormalities due to kainate with Gd-DTPA- Gadomer-17 and polylysine-Gd-DTPA were observed mainly in the region of hippocampus and in the areas not protected by the blood-brain-barier (BBB).
    Vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 440, Suppl. 5, 2000, str. R 153- R 154)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 946810

vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Vol. 440, Suppl. 5, 2000, str. R 153- R 154)

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