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  • Prenatalno odkrivanje Downovega sindroma s presejalnimi testi v zgodnji nosečnosti = Prenatal screening tests for Down syndrome in early pregnancy
    Pušenjak, Stanko ...
    Early amniocentesis is globally most often used for the detection of Down syndrome (DS) in pregnant women after 35 years of age. Ideally, this test discovers 30% of DS, but 70% of children with DS ... are born, however, to the women younger than 35 years. 1% of abortion rate after karyotyping, rare incidence of DS in young women and high price do not allow the implementation of karyotyping in all the pregnant women. perinatologists all over the world are therefore in search of a screening test, which would bring the detection of DS to more acceptable values. A few tenths of US characteristics of fetusesand biochemical markers in serum of of pregnant women have already beendiscovered, which in a higher percent appear in fetuses with DS. Lately, the triple hormonal test (THT) and nuchal translucency (NT) are gaining the priority. Both enable 2-3 times better detection as the present karyotyping inpregnant women after 35 years of age. Ethical problems and new stressfull situations arise due to falsely positive and falsely negative screening results. In such cases the consulting poses high demands as the falsely positive test results for DS can present a bigger risk for other defects in fetus development or pregnancy complications.
    Vir: Zdravstveno varstvo : Slovenian journal of public health. - ISSN 0351-0026 (Letn. 37, št. 11-12, 1998, str. 523-526)
    Vrsta gradiva - članek, sestavni del
    Leto - 1998
    Jezik - slovenski
    COBISS.SI-ID - 9674201

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