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  • Under what conditions signal transduction pathways are highly flexible in response to external forcing? : a case study on calcium oscillations
    Marhl, Marko ; Schuster, Stefan
    Sensivity and flexibility are typical properties of biological systems. These properties are here investigated in a model for simple and complex intracellular calcium oscillations. In particular, the ... influence of external periodic forcing is studied. The main point of the study is to compare responses of the system in a chaotic regime with those obtained in a regular periodic regime. We show that the response to external signals in terms of therange of synchronization is not significantly different in regular and chaotic Ca2+ oscillations. However, both types of oscillation are highly felxible in regimes with weak dissipation. Therefore, we conclude that dissipation of free energy is a suitable index characterizing flexibility. For biological systems this appears to be of special importance since for thermodynamic reasons, notably in view of low free energy consumption, dissipation should be minimized
    Vir: Journal of theoretical biology. - ISSN 0022-5193 (224, 2003, str. 491-500)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2003
    Jezik - angleški
    COBISS.SI-ID - 12786184

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