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Landi, Lorenza; Chiari, Rita; Tiseo, Marcello; D'Incà, Federica; Dazzi, Claudio; Chella, Antonio; Delmonte, Angelo; Bonanno, Laura; Giannarelli, Diana; Cortinovis, Diego Luigi; de Marinis, Filippo; Borra, Gloria; Morabito, Alessandro; Gridelli, Cesare; Galetta, Domenico; Barbieri, Fausto; Grossi, Francesco; Capelletto, Enrica; Minuti, Gabriele; Mazzoni, Francesca; Verusio, Claudio; Bria, Emilio; Alì, Greta; Bruno, Rossella; Proietti, Agnese; Fontanini, Gabriella; Crinò, Lucio; Cappuzzo, Federico
Clinical cancer research, 12/2019, Letnik: 25, Številka: 24Journal Article
-deregulated NSCLC represents an urgent clinical need because of unfavorable prognosis and lack of specific therapies. Although recent studies have suggested a potential role for crizotinib in patients harboring amplification or exon 14 mutations, no conclusive data are currently available. This study aimed at investigating activity of crizotinib in patients harboring or alterations. Patients with pretreated advanced NSCLC and evidence of rearrangements (cohort A) or deregulation (amplification, ratio MET/CEP7 >2.2 or exon 14 mutations, cohort B) were treated with crizotinib 250 mg twice daily orally. The coprimary endpoint was objective response rate in the two cohorts. From December 2014 to March 2017, 505 patients were screened and a total of 52 patients (26 patients per cohort) were enrolled onto the study. At data cutoff of September 2017, in cohort A, objective response rate was 65%, and median progression-free survival and overall survival were 22.8 months 95% confidence interval (CI) 15.2-30.3 and not reached, respectively. In cohort B, objective response rate was 27%, median progression-free survival was 4.4 months (95% CI 3.0-5.8), and overall survival was 5.4 months (95% CI, 4.2-6.5). No difference in any clinical endpoint was observed between -amplified and exon 14-mutated patients. No response was observed among the 5 patients with cooccurrence of a second gene alteration. No unexpected toxicity was observed in both cohorts. Crizotinib induces response in a fraction of -deregulated NSCLC. Additional studies and innovative therapies are urgently needed.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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