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Rienmuller, Theresa; Shrestha, Niroj; Polz, Mathias; Stoppacher, Sara; Ziesel, Daniel; Migliaccio, Ludovico; Pelzmann, Brigitte; Lang, Petra; Zorn-Pauly, Klaus; Langthaler, Sonja; Opancar, Aleksandar; Baumgartner, Christian; Ucal, Muammer; Schindl, Rainer; Derek, Vedran; Scheruebel, Susanne
IEEE transactions on biomedical engineering 71, Številka: 6Journal Article
This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels (I ) in Guinea pig ventricular cardiomyocytes. Whole-cell patch-clamp recordings were employed to examine light-triggered OEPC mediated I activation, integrating the channel's kinetic properties into a multicompartment cell model to take intracellular ion concentrations into account. A multidomain model was additionally incorporated to evaluate effects of OEPC-mediated stimulation. The final model combines external stimulation, multicompartmental cell simulation, and a patch-clamp amplifier equivalent circuit to assess the impact on achievable intracellular voltage changes. Light pulses activated I , with amplitudes similar to voltage-clamp activation and high sensitivity to the L-type Ca channel blocker, nifedipine. Light-triggered I inactivation exhibited kinetic parameters comparable to voltage-induced inactivation. OEPC-mediated activation of I demonstrates their potential for nongenetic optical modulation of cellular physiology potentially paving the way for the development of innovative therapies in cardiovascular health. The integrated model proves the light-mediated activation of I and advances the understanding of the interplay between the patch-clamp amplifier and external stimulation devices. Treating cardiac conduction disorders by minimal-invasive means without genetic modifications could advance therapeutic approaches increasing patients' quality of life compared with conventional methods employing electronic devices.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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