•Q-switch Ho:Sc2SiO5 laser modulated by a acousto-optic modulator and a Cr2+:ZnSe is reported for the first time.•The maximum peak power is obviously higher than the actively and passively Q-switch ones.•Ho:Sc2SiO5 possesses large energy splitting, wide absorption and emission spectrum. A double Q-switch (DQS) Ho:Sc2SiO5 laser modulated by a acousto-optic modulators (AOM) combined with a Cr2+:ZnSe saturable absorber (SA) was reported for the first time. The actively Q-switch (AQS) and passively Q-switch (PQS) were also studied. For the DQS mode, a maximum average output power of 2.49W under the incident pump power of 12.5W was obtained, corresponding to a slope efficiency of 24%. The characteristics of the DQS Ho:SSO laser versus different repetition frequencies (RF) of the AOM were researched. The maximum single-pulse energy of the DQS Ho:SSO laser was calculated to 1.98mJ. The maximum peak power of the DQS Ho:SSO laser was 49.5kW. The output beam quality factor M2 of DQS Ho:SSO laser was measured to be 1.15 with the highest peak power by knife-edge method at different positions.