Interventional procedures are accompanied with high levels of patient exposure and even with the possibility of radiation skin damage. That’s why any actions leading to reduction of patients’ exposure levels are of utmost importance. Implementation of diagnostic reference levels is considered to be one of the most successful actions to reduce patient exposure levels. However the basic concept of diagnostic reference levels cannot be used for interventional radiology due to fact that procedures are not standardized. The article studies the main difficulties in applying the standard concept of diagnostic reference levels for interventional radiology procedures and proposes a new concept, taking into account the specifics of these procedures; the domestic and international documents are analyzed. The list of interventional procedures for diagnostic reference levels establishment is suggested based on the statistical data on performed procedures in the Russian Federation. The results of this study were used for the new Russian guidelines “Optimization of radiation protection of patients undergoing medical radiation diagnostic examinations through the use of diagnostic reference levels”.