van Kempen, Michel; Kim, Stephanie S; Tumescheit, Charlotte; Mirdita, Milot; Lee, Jeongjae; Gilchrist, Cameron L M; Söding, Johannes; Steinegger, Martin
Nature biotechnology,
02/2024, Letnik:
42, Številka:
2
Journal Article
As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively.
