The nature of dark matter remains a central question in particle physics, cosmology, and astrophysics. The prevailing hypothesis postulates that dark matter consists of particles that interact only weakly with Standard Model particles. However, the knowledge of dark matter properties beyond these interactions is limited. This study explores a scenario involving a dark photon as a mediator between dark matter and the Standard Model, akin to the photon's role in electromagnetism. Recent cosmological and experimental evidence impose constraints on this scenario, focusing on results from direct detection experiments such as PICO-60, XENON-1T, and PANDAX-4T. The results reveal severe constraints, effectively closing the window for laboratory searches for dark photons as mediators between the Standard Model and the dark sector (dark electrons) in the secluded dark matter scenario. The findings underscore the need for alternative explanations and offer fresh perspectives on the ongoing quest to understand dark matter and its interactions since they are nearly independent of the dark electron fraction content for the total dark matter. This analysis significantly narrows down the parameter space for thermal dark matter scenarios involving a dark photon portal, reinforcing the urgency of exploring alternative models and designing new experiments to unravel the mysteries surrounding the nature of dark matter.