The objective of change detection (CD) is to identify the altered region between dual-temporal images. In pursuit of more precise change maps, numerous state-of-the-art (SOTA) methods design neural networks with robust discriminative capabilities. The convolutional neural network (CNN)-transformer model is specifically designed to integrate the strengths of the CNN and transformer, facilitating effective coupling of feature information. However, previous CNN-transformer studies have not effectively mitigated the interference of feature distribution differences as well as pseudovariations between two images due to cloud occlusion, imaging conditions, and other factors. In this article, we propose a domain adaptive and interactive differential attention network (DA-IDANet). This model incorporates domain adaptive constraints (DACs) to mitigate the interference of pseudovariations by mapping the two images to the same deep feature space for feature alignment. Furthermore, we designed the interactive differential attention module (IDAM), which effectively improves the feature representation and promotes the coupling of interactive differential discriminant information, thereby minimizing the impact of irrelevant information. Experiments on four datasets demonstrate the superior validity and robustness of our proposed model compared to other SOTA methods, as evident from both quantitative analysis and qualitative comparisons. The code will be available online ( https://github.com/Jyl199904/DA-IDANet ).