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  • Nitric oxide destroys zinc-...
    Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9
    Kröncke, K D; Fehsel, K; Schmidt, T; Zenke, F T; Dasting, I; Wesener, J R; Bettermann, H; Breunig, K D; Kolb-Bachofen, V

    Biochemical and biophysical research communications, 04/1994, Letnik: 200, Številka: 2
    Journal Article

    Nitric oxide, generated from S-nitrosocysteine or applied as gas mediates metal ion release from the Zn2+/Cd(2+)-complexing protein metallothionein via oxidation of SH-groups. Time-dependent S-nitrosylation and subsequent disulfide formation of metallothionein are demonstrated. Furthermore, nitric oxide inhibits DNA binding activity of the yeast transcription factor LAC9 containing a zinc finger like DNA binding domain. These results show that nitric oxide interacts with and destroys zinc-sulfur clusters in proteins.

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