BACKGROUND: Bilateral strength asymmetry and fatigue predispose athletes to various injuries and conventional methods appear to be poor predictors of lower extremity muscular performance under NF conditions. OBJECTIVE: The purpose of the study was to compare the conventional Hcon/Qcon (HQR) ratio and the dynamic control ratio (DCR: Hecc/Qcon) under non-fatiguing (NF) and fatiguing (F) conditions and verify the effects of heavy-intensity constant running and cycling exercise on the isokinetic performance. METHODS: Twenty healthy male participants performed running and cycling VO2max at work-rate associated with the achievement of VO2max (TTE). Isokinetic muscle strength performance was tested at 60 and 180∘/s before and after these sessions with 48-hour intervals. Quadriceps (QFR) and hamstring (HFR) muscle fatigue rates were also calculated during these sessions. Blood lactate concentration was measured before and two-minutes after running and cycling TTE. RESULTS: No between-condition differences were found for the HQR while the DCR decreased significantly at 180∘/s following cycling and running sessions (p< 0.05). Cycling TTE was positively correlated with in dominant (r= 0.535, p= 0.015) and non-dominant (r= 0.446, p= 0.048) QFR. Positive correlations were also found between running TTE and dominant (r= 0.500, p= 0.25) and non-dominant (r= 0.465, p= 0.039) HFR. CONCLUSIONS: The DCR obtained at fast angular velocities following a strenuous exercise seems to be the best indicator of muscle performance while its assessment under F conditions reveals higher ratios compared to NF conditions and conventional methods.