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Deshpande, Rajiv S.; Langham, Michael C.; Lee, Hyunyeol; Kamona, Nada; Wehrli, Felix W.
Magnetic resonance in medicine, 20/May , Letnik: 91, Številka: 5Journal Article
Purpose Renal metabolic rate of oxygen (rMRO2) is a potentially important biomarker of kidney function. The key parameters for rMRO2 quantification include blood flow rate (BFR) and venous oxygen saturation (SvO2) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO2. A pulse sequence to facilitate bilateral rMRO2 quantification is introduced. Methods To quantify bilateral rMRO2, measurements of BFR and SvO2 are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an expression for bilateral rMRO2. The recently reported K‐MOTIVE pulse sequence was implemented at four locations: left kidney, right kidney, suprarenal IVC, and infrarenal IVC. A dual‐band variant of K‐MOTIVE (db‐K‐MOTIVE) was developed by incorporating simultaneous‐multi‐slice imaging principles. The sequence simultaneously measures BFR and SvO2 at suprarenal and infrarenal locations in a single pass of 21 s, yielding bilateral rMRO2. Results SvO2 and BFR are higher in suprarenal versus infrarenal IVC, and the renal veins are highly oxygenated (SvO2 >90%). Bilateral rMRO2 quantified in 10 healthy subjects (8 M, 30 ± 8 y) was found to be 291 ± 247 and 349 ± 300 (μmolO2/min)/100 g, derived from K‐MOTIVE and db‐K‐MOTIVE, respectively. In comparison, total rMRO2 from combining left and right was 329 ± 273 (μmolO2/min)/100 g. Conclusion The present work demonstrates that bilateral rMRO2 quantification is feasible with fair reproducibility and physiological plausibility. The indirect method is a promising approach to compute bilateral rMRO2 when individual rMRO2 quantification is difficult.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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