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Tsimikas, Sotirios; Karwatowska-Prokopczuk, Ewa; Gouni-Berthold, Ioanna; Tardif, Jean-Claude; Baum, Seth J; Steinhagen-Thiessen, Elizabeth; Shapiro, Michael D; Stroes, Erik S; Moriarty, Patrick M; Nordestgaard, Børge G; Xia, Shuting; Guerriero, Jonathan; Viney, Nicholas J; O’Dea, Louis; Witztum, Joseph L
New England journal of medicine/The New England journal of medicine, 01/2020, Letnik: 382, Številka: 3Journal Article
Elevated levels of lipoprotein(a) in the plasma are a risk factor for cardiovascular disease, and lowering levels can be achieved with antisense oligonucleotide targeting LPA messenger RNA, which encodes lipoprotein(a). This trial tested whether the same effect can be achieved in persons with established cardiovascular disease.
