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Bogush, T. A.; Spiridonova, K. S.; Bogush, E. A.; Grishanina, A. N.; Scherbakov, A. M.; Volkova, M. I.; Safarov, Z. M.; Matveev, V. B.; Kosorukov, V. S.
Moscow University chemistry bulletin, 12/2023, Letnik: 78, Številka: 6Journal Article
The expression of PD-L1 protein is quantified in 56 samples of urothelial bladder cancer (BC). PD-L1 expression is detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) this score is 1.5 times higher than in muscle-invasive bladder cancer (MIBC) ( p = 0.001). High PD-L1 expression level (≥30%) is observed in 20% of MIBC samples and among NMIBC tumors in 68% of cases, i.e., 3.4 times more often ( p = 0.0004). The last fact justifies the prospect of starting therapy with immune checkpoint inhibitors at the onset of the disease for NMIBC.
