The environmentally friendly, low toxic or nontoxic, and functional material to solve the needs of agricultural development are the key to current scientific research. Here, acrylic thiazole copolymer clusters (AcTPCs) were successfully synthesized by using common methacrylic acid as an induced source, combined with the antimicrobial monomers acrylic thiazole (AcT) and Zn2+, which are of great value for agricultural applications. Utilizing the “cluster effect,” under the synergistic effect of the fully exposed active ingredients, they not only have long‐lasting antimicrobial effects against bacteria and fungi, but also promote the growth of plant roots and stems and increase the chlorophyll content. Therefore, this study provides a novel, environmental‐friendly, and low‐toxic method to solve the microbe infection problem, which is expected to improve the agriculture. The environmentally friendly and low‐toxic acrylic thiazole copolymer clusters (AcTPCs) were constructed to inhibit the growth of bacteria and fungi. It has long‐acting antibacterial efficiency more than 7 days and promotes the growth of corn roots, stems, leaves, and so on, which is expected to solve the microbe infection problem and improve the agriculture.