Objectives The aim of this systematic review was to identify and summarize the available literature related to CAD/CAM‐fabricated implant‐supported restorations. Materials and methods A systematic review of the literature was conducted using the Cochrane Library and the US Library of Medicine, National Institute of Health databases (Pubmed). Several search runs with specific search terms were performed and combined. All published papers available on the databases up to January 15, 2015 were considered with primarily no restrictions. Results About 12 of 3484 identified papers met the inclusion criteria and were analyzed in the present review. One paper reported results on implant‐supported single crowns (SCs), one on partial fixed dental prostheses (FDPs), and 10 papers reported results on full‐arch screw‐retained FDPs. Publications on SCs and FDPs were very limited but it was possible to identify 10 papers reporting adequate results on full‐arch screw‐retained FDPs. Survival rates ranged between 92% and 100% with observation times of 1–10 years. Conclusion The available data provided promising results for CAD/CAM‐fabricated implant‐supported restorations; nonetheless, current evidence is limited due to the quality of available studies and the paucity of data on long‐term clinical outcomes of 5 years or more. In the sense of an evidence‐based dentistry, the authors recommend further studies designed as randomized controlled clinical trials and reported according to the CONSORT statement.