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Hussain, Maha; Tangen, Catherine M; Berry, Donna L; Higano, Celestia S; Crawford, E. David; Liu, Glenn; Wilding, George; Prescott, Stephen; Kanaga Sundaram, Subramanian; Small, Eric Jay; Dawson, Nancy Ann; Donnelly, Bryan J; Venner, Peter M; Vaishampayan, Ulka N; Schellhammer, Paul F; Quinn, David I; Raghavan, Derek; Ely, Benjamin; Moinpour, Carol M; Vogelzang, Nicholas J; Thompson, Ian M
The New England journal of medicine, 04/2013, Letnik: 368, Številka: 14Journal Article
Despite theoretical benefits of intermittent as compared with continuous androgen-deprivation therapy in patients with metastatic prostate cancer, intermittent therapy did not result in longer survival or long-term improvement in quality of life. Prostate cancer is an androgen-dependent disease, and continuous androgen deprivation has been the standard therapy for metastatic hormone-sensitive disease. Despite a high response rate, resistance to androgen-deprivation therapy occurs in most patients, resulting in a median survival of 2.5 to 3 years. 1 , 2 There is evidence suggesting that progression to castration resistance is adaptive in part, and pathways involving the androgen receptor, as well as cell-survival pathways independent of the androgen receptor, have been implicated. 3 , 4 Data from an androgen-dependent tumor model have suggested that androgen withdrawal alters the ratio of putative stem cells in the tumor-cell population. 5 Initially, differentiated . . .
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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