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Mirza, Mansoor R; Monk, Bradley J; Herrstedt, Jørn; Oza, Amit M; Mahner, Sven; Redondo, Andrés; Fabbro, Michel; Ledermann, Jonathan A; Lorusso, Domenica; Vergote, Ignace; Ben-Baruch, Noa E; Marth, Christian; Mądry, Radosław; Christensen, René D; Berek, Jonathan S; Dørum, Anne; Tinker, Anna V; du Bois, Andreas; González-Martín, Antonio; Follana, Philippe; Benigno, Benedict; Rosenberg, Per; Gilbert, Lucy; Rimel, Bobbie J; Buscema, Joseph; Balser, John P; Agarwal, Shefali; Matulonis, Ursula A
New England journal of medicine/The New England journal of medicine, 12/2016, Letnik: 375, Številka: 22Journal Article, Web Resource
Among patients with platinum-sensitive, recurrent ovarian cancer, the use of niraparib, a PARP inhibitor, was associated with a significantly longer duration of progression-free survival than placebo, with moderate bone marrow toxicity. Ovarian cancer is a leading cause of death from gynecologic cancers worldwide. 1 , 2 Despite a high initial response rate to platinum and taxane treatment in patients with advanced cancer, the effectiveness of the treatments diminishes over time, and most patients have a relapse. 3 Platinum retreatment is used in patients in whom there is an assumed platinum sensitivity, with diminishing effectiveness and a cumulative increase in toxicity. 3 Niraparib is a highly selective inhibitor of poly(adenosine diphosphate ADP–ribose) polymerase (PARP) 1/2, 4 nuclear proteins that detect DNA damage and promote its repair. Clinical studies have evaluated PARP inhibitors in patients with recurrent ovarian . . .
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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