A bstract In this work we perform an analysis of the recent AMS-02 antiproton flux and the antiproton-to-proton ratio in the framework of simplified dark matter models. To predict the AMS-02 observables we adopt the propagation and injection parameters determined by the observed fluxes of nuclei. We assume that the dark matter particle is a Dirac fermionic dark matter, with leptophobic pseudoscalar or axialvector mediator that couples only to Standard Model quarks and dark matter particles. We find that the AMS-02 observations are consistent with the dark matter framework within the uncertainties. The antiproton data prefer a dark matter (mediator) mass in the 700 GeV-5 TeV region for the annihilation with pseudoscalar mediator and greater than 700 GeV (200 GeV-1 TeV) for the annihilation with axialvector mediator, respectively, at about 68% confidence level. The AMS-02 data require an effective dark matter annihilation cross section in the region of 1×10 −25 −1×10 −24 (1×10 −25 −4×10 −24 ) cm 3 /sforthesimplifiedmodelwithpseudoscalar (axialvector) mediator. The constraints from the LHC and Fermi-LAT are also discussed.