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Hayakawa, N.; Sato, Y.; Nagasaka, A.; Mano, Y.; Nagasaka, T.; Nakai, A.; Iwase, K.; Yoshida, S.
Journal of endocrinological investigation, 04/2017, Letnik: 40, Številka: 4Journal Article
Introduction High DNA polymerase β activity has been observed in the thyroid tissue of patients with Graves’ disease (Nagasaka et al. in Metabolism 37:1051–1054, 1988 ). This fact aroused our interest in whether the alteration of DNA polymerase β activity depends on DNA polymerase β (DNA poly β) mRNA levels, which may be modulated by thyroid-stimulating hormone (TSH) or thyroid-stimulating substances, i.e. TSH receptor antibody (TRAb). Result Addition of TSH or TRAb to primary cultures of Graves’ disease thyroid cells for 4 h led to no increase in DNA poly β mRNA levels. In contrast, thyroid hormone synthesizing enzyme, peroxidase, mRNA levels increased fivefold after coculture with TSH and TRAb, even though DNA poly β activity and mRNA levels are already significantly higher in Graves’ disease thyroid tissues, compared with normal thyroid tissue. Discussion These results indicate that DNA poly β expression in Graves’ disease thyroid cells may be maximally activated or plateau in response to thyroid-stimulating immunoglobulins, or that the activation of to poly β expression may occur via pathways other than the G protein and cyclic AMP system.
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