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Rosenson, Robert S; Burgess, Lesley J; Ebenbichler, Christoph F; Baum, Seth J; Stroes, Erik S.G; Ali, Shazia; Khilla, Nagwa; Hamlin, Robert; Pordy, Robert; Dong, Yuping; Son, Vladimir; Gaudet, Daniel
The New England journal of medicine, 12/2020, Letnik: 383, Številka: 24Journal Article
Angiopoietin-like 3 is an inhibitor of lipoprotein lipase. Evinacumab is a monoclonal antibody that inhibits angiopoietin-like 3, activating lipoprotein lipase. In patients with hypercholesterolemia that is refractory to statin and PCSK9 inhibitor therapy, the use of evinacumab reduced plasma lipid levels by more than 50% at the maximum dose.
