Display omitted •Very long wall relaxation times were obtained reproducibly in uncoated glass cells.•“Aging” process of wall relaxation in the same cell was identified and eliminated.•SF6 and CO2 were identified as efficient destroyers of Xe-dimers.•Strong dependence of van der Waals relaxation on the isotope concentration.•In summary this yields storage times for HP-129Xe of 5–7h at low magnetic fields. The spin–lattice relaxation time T1 of hyperpolarized (HP)-129Xe was improved at typical storage conditions (i.e. low and homogeneous magnetic fields). Very long wall relaxation times T1wall of about 18h were observed in uncoated, spherical GE180 glass cells of ∅=10cm which were free of rubidium and not permanently sealed but attached to a standard glass stopcock. An “aging” process of the wall relaxation was identified by repeating measurements on the same cell. This effect could be easily removed by repeating the initial cleaning procedure. In this way, a constant wall relaxation was ensured. The Xe nuclear spin-relaxation rate 1/T1Xe–Xe due to van der Waals molecules was investigated too, by admixing three different buffer gases (N2, SF6 and CO2). Especially CO2 exhibited an unexpected high efficiency (r) in shortening the lifetime of the Xe–Xe dimers and hence prolonging the total T1 relaxation even further. These measurements also yielded an improved accuracy for the van der Waals relaxation for pure Xe (with 85% 129Xe) of T1Xe–Xe=(4.6±0.1)h. Repeating the measurements with HP 129Xe in natural abundance in mixtures with SF6, a strong dependence of T1Xe–Xe and r on the isotopic enrichment was observed, uncovering a shorter T1Xe–Xe relaxation for the 129Xe in natural composition as compared to the 85% isotopically enriched gas.