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Liu, Chen; Wang, Dongwei; Song, Ying; Lu, Songsong; Zhao, Jingzhong; Wang, Hui
International immunopharmacology, March 2018, 2018-Mar, 2018-03-00, 20180301, Letnik: 56Journal Article
As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesis of autoimmune diseases. However, the role of TFR cells in systemic lupus erythematosus (SLE) remains unclear. This study revealed a significant increase of CD4+CXCR5+FOXP3+ TFR cells in peripheral blood of SLE patients compared with healthy controls. Meanwhile, the suppression ability of circulating TFR cells was not altered. The ratios of TFR/TFH were increased in SLE patients and the frequency of TFR was positively correlated with auto-antibodies and SLEDAI scores of SLE patients. Our results demonstrated that circulating TFR cells were increased during SLE, which suggested that elevated TFR might be a response to the pathogenesis of SLE to suppress TFH function and may provide novel insight for the pathogenesis of SLE. •CD4+CXCR5+FoxP3+ TFR cells in the peripheral blood of SLE patients are increased compared with healthy controls.•Ratio of TFR/TFH was significantly elevated in SLE patients.•TFR was positively correlated with auto-antibodies and clinical severity of SLE patients.•Suppressive capacity of circulating TFR cells was not altered in SLE patients.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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