E-viri
Recenzirano
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Pagani, Filippo; Colecchia, Maurizio; Sepe, Pierangela; Apollonio, Giulia; Claps, Melanie; Verzoni, Elena; de Braud, Filippo; Procopio, Giuseppe
Cancer treatment reviews, 09/2019, Letnik: 79Journal Article
•Collecting ducts carcinoma (CDC) is a rare and aggressive disease.•Incurable when metastatic, chemotherapy has palliative role with poor responses.•Case reports with targeted therapy and encouraging results, scarce strong evidences.•Molecular characterize CDC to find recurrent alterations and potential targets.•New biological driven approaches, immune-checkpoint inhibitors are feasible. Collecting ducts carcinoma (CDC) is a rare and aggressive histological subtype of renal cancer accounting for only 1% of renal tumors. Usually patients present in bad clinical conditions due to a symptomatic disease with synchronous metastasis. Due to the rarity of CDC, data from prospective trials evaluating the best treatment for these patients are limited. The prognosis is poor with a median overall survival of around 11 months for patients with metastatic disease. The best treatment option today is considered a doublet chemotherapy with platinum salt plus gemcitabine as a result from a prospective phase II trial, but survival outcomes remain unsatisfactory. The interest in the in-depth understanding the biology of this orphan disease is growing, leading to find potential new biological-driven treatment approaches. Here we review the up-to-date literature evidences to address the best management of this rare and unfavorable clinical condition.
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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