The Evros deltaic plain (North Aegean Sea, Greece) covers an area of 188 km 2 and is shared by Greece and Turkey by its current main channel. This paper investigates deltaic plain evolution during the last seven decades (1945-2017), taking into consideration human interventions and their impacts on deltaic processes. Outcomes indicate that the construction of more than 25 major dams in the Evros River catchment resulted in >80% reduction in fluvial suspended load. Moreover, the alignment and relocation of the main distributary channel to the southeast was accompanied by the transformation of >40% of the deltaic plain to agricultural land. The combination of human interventions supports the coastline advance of the active main mouth (current rate of 3.9 *10 −3  km 2 /yr), retreat of the old (abandoned) Evros mouth (current rate 7.7 *10 −3  km 2 /yr), and signs of remarkable vulnerability in the middle mouth area.