A framework for incorporating probabilistic seismic performance during prescriptive design of reinforced concrete buildings using Indian building codes is presented. The second-generation performance-based design procedure is considered. Thirty special RC frame buildings have been numerically analyzed through nonlinear static and time history analyses. Effects of seismicity, building height, bay-width, and number of bays on building performance are investigated. A generalized expression for the overstrength factor is proposed. Expression for response reduction factor to achieve the desired level of performance objective is also proposed. Low- and mid-rise buildings in the high seismic region designed using current codes are found to be deficient.