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Liu, Huaqing; Altenbach, Robert J.; Diaz, Gilbert J.; Manelli, Arlene M.; Martin, Ruth L.; Miller, Thomas R.; Esbenshade, Timothy A.; Brioni, Jorge D.; Cowart, Marlon D.
Bioorganic & medicinal chemistry letters, 06/2010, Letnik: 20, Številka: 11Journal Article
A novel series of histamine H3 antagonists containing quinoline core was disclosed. Compound 51 showed 50pM affinity for human histamine H3 in the radio ligand binding assay. A series of quinoline containing histamine H3 antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring.
