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  • Synthesis of guanidines via...
    Rong, Hao-Jie; Yang, Cui-Feng; Chen, Tao; Wang, Yong-Qiang; Ning, Bin-Ke

    Tetrahedron letters, 08/2019, Letnik: 60, Številka: 34
    Journal Article

    Display omitted •The I2 mediated desulfurization of N,N′-di-Boc-thiourea was firstly developed.•A practical protocol by using N,N′-di-Boc-thiourea and iodine as guanylating reagents.•Wide substrate scope with 52–98% yield. The I2 mediated desulfurization of N,N′-di-Boc-thiourea was developed. Various primary amines, including sterically and electronically deactivated primary amines, were transformed into the corresponding bis-Boc protected guanidines under mild conditions.