The purpose of this study was to develop and evaluate the effectiveness of a quick response code–based nursing education program to improve the competence of operation and recovery room nurses. An experimental methodological design was used to develop a quick response code–based nursing educational program and analyze its effects and nursesʼ satisfaction with its use. The quick response code–based nursing education program was developed in five steps based on the ADDIE modelanalysis, design, development, implementation, and evaluation. The program was built on smartphones, and a Web site was linked to it. After testing the program for 40 days, nursesʼ attitudes toward various medical devices were significantly less negative. Nurses were able to use a large number of medical devices and were highly satisfied and willing to engage with the quick response code–based nursing educational program. In the context of nursing education, introducing educational content using quick response codes helps to improve nursesʼ knowledge and competence in providing high-quality nursing care and medical services.